細胞粘着における新たな展望:RGDとインテグリン

E Ruoslahti¹, M D Pierschbacher

¹La Jolla Cancer Research Foundation, CA 92037.

Science (New York, N.Y.)

|October 23, 1987

まとめ

細胞粘着は,アルギニン・グリシン・アスパルティック酸 (RGD) 配列を持つタンパク質がインテグリン受容体と結合する分子相互作用を含む. この相互作用は,細胞の固定,移動,信号伝達に不可欠です.

科学分野:

分子生物学は分子生物学である.
細胞生物学細胞生物学
バイオケミストリーバイオケミストリー

背景:

細胞結合は多細胞生物にとって根本的なものです.
細胞外マトリックスと血液タンパク質には,しばしば細胞認識のためのアルギニン・グリシン・アスパルティック酸 (RGD) 配列が含まれています.
インテグリンは,これらのRGD配列に結合する細胞表面受容体です.

研究の目的:

細胞結合の分子メカニズムを解明する.
細胞認識と結合におけるRGD配列とインテグリンの役割を記述する.
細胞プロセスにおけるRGD-インテグリンシステムの機能的重要性を強調する.

主な方法:

細胞粘着分子に関する既存の文献のレビュー.
RGDを含むタンパク質の構造と機能の分析.
インテグリン系受容体とその結合特異性の検討.

主要な成果:

10種類以上のRGDを含む粘着タンパク質と,少なくとも同数のインテグリン受容体を特定しました.
インテグリンが様々な粘着性タンパク質のRGD配列を認識することを示した.
認識特異性におけるRGD配列適合の重要な役割を強調した.
細胞外マトリックスと細胞内細胞骨格との接続をインテグリン経由で確立した.

結論:

RGD-インテグリンシステムは,細胞粘着に不可欠な多機能認識メカニズムです.
このシステムは,細胞に固定場所を提供し,移動を助け,分化と成長のための信号を送信します.
このシステムに関するさらなる研究は,様々な生理学的および病理学的プロセスに関する洞察を明らかにすることができます.

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