pituitary細胞に対するインタールイキン-1の直接作用によって複数のホルモンの放出
E W Bernton1, J E Beach, J W Holaday
1Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Science (New York, N.Y.)
|October 23, 1987
まとめ
インターリューキン-1 (IL-1) は前垂体ホルモン分泌に直接影響する. この免疫信号分子は,ACTHやTSHのような重要なホルモンを刺激し,同時にプロラクチンを阻害し,感染に対する代謝反応に影響します.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 免疫学 免疫学とは
- 神経科学は神経科学である.
背景:
- バクテリアのエンドトキシンが前部下垂体ホルモンの放出を刺激し,歴史的に下垂体機能をテストするために使用されました.
- エンドトキシンは,マクロファージとモノサイトによって生成されるピロゲンタンパク質であるインタールユーキン-1 (IL-1) を誘導する.
- 下垂体ホルモンの分泌に対するIL-1の直接的な役割については,さらなる調査が必要である.
研究 の 目的:
- ネズミの前垂体細胞からのホルモン分泌に対するインタールイキン-1 (IL-1) の直接的な効果を in vitro で調査する.
- IL-1によって影響を受ける特定の下垂体ホルモンと,濃度依存の反応を決定する.
主な方法:
- モノレイヤー培養でラットの下垂体細胞を活用した.
- リコンビネントヒトIL-1βを濃度範囲 (10−9M~10−12M) で投与した.
- 培養スーパーナタンにおけるホルモンレベルを測定し,IL-1抗体中和の効果を評価した.
主要な成果:
- IL-1βは,腎上腺皮質ホルモン (ACTH),ルテイン化ホルモン (LH),成長ホルモン (GH),甲状腺刺激ホルモン (TSH) の分泌を著しく刺激した.
- プロラクチン分泌は,同様のIL-1濃度によって抑制された.
- 観察された効果は,IL-1に対する抗体によって中和され,特異性を確認しました.
結論:
- インタールイキン-1 (IL-1) は,前垂体ホルモン分泌を直接調節する.
- IL-1は,感染症やストレス状態における代謝適応の重要な調節体として作用する可能性があります.
- 免疫細胞からの外周IL-1シグナル伝達は,体内では下垂体ホルモンの放出に影響を与える可能性があります.
関連する概念動画
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01:37Hypothalamic-Pituitary Axis
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01:26Secondary Messengers in Hormone Action
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01:22Target Cell Response to Hormones
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01:19Regulation of Hormone Secretion
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
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01:27Hormones of the Pituitary Gland
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The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...