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Updated: Mar 7, 2026

In Vitro Resident Memory CD8 T Cell Differentiation Using Epithelial Organoid-T Cell Co-culture System
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In Vitro Resident Memory CD8 T Cell Differentiation Using Epithelial Organoid-T Cell Co-culture System

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組織内記憶T細胞の生存には,外因的な脂質の吸収と代謝が必要である

Youdong Pan1, Tian Tian1, Chang Ook Park1

  • 1Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Harvard Medical School, Boston, Massachusetts, USA.

Nature
|February 21, 2017
PubMed
まとめ

組織内記憶T (TRM) 細胞は,脂肪酸結合タンパク質4と5 (FABP4/5) を使用して,自由脂肪酸を吸収し,長期間生存と病原体保護のためにミトコンドリアの代謝を促進します. これはTRM細胞の持続性と機能のための新しい経路を強調しています.

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