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人間のDNAプリマースの [4Fe4S] クラスタは,DNA電荷輸送を用いた酸化還元スイッチとして機能する

Elizabeth O'Brien1, Marilyn E Holt2, Matthew K Thompson2

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|February 25, 2017
PubMed
まとめ

人間のDNAプリマースは,DNA電荷輸送と [4Fe4S]クラスターを使用して,DNA合成の開始を調節します. このメカニズムはDNA結合を制御し,複製中にポリメラーゼの相互作用を容易にします.

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