まず 生まれたのは ウイルス か 卵 か
1The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|February 25, 2017
まとめ
3つの研究は,HAP2タンパク質がゲメットの細胞融合の鍵であることを明らかにしています. このタンパク質は構造的にはウイルス融合タンパク質に類似しており,細胞とウイルス細胞の融合メカニズムの共通の進化的起源を示唆しています.
科学分野:
- 細胞生物学
- ウイルス学
- 遺伝学
背景:
- 細胞融合は 生殖と発達に不可欠な基本的な生物学的プロセスです
- ウイルスの融合タンパク質は,宿主細胞へのウイルスの侵入を媒介する.
- ゲメット融合の背後にある分子メカニズムは,まだ完全に理解されていません.
研究 の 目的:
- ゲメト融合に関与する 分子プレーヤーを調査する
- ゲメット融合タンパク質とウイルス融合タンパク質の構造的・機能的関係を決定する.
主な方法:
- 比較ゲノム分析
- タンパク質構造の予測
- ゲメット融合のための機能的測定
主要な成果:
- シングルパストランスメブランタンパク質HAP2は,ゲメット融合の重要な媒介体として特定されました.
- HAP2は,ウイルスに見られるクラスII融合タンパク質と構造的に有意なホモロジーを示している.
- この類似性は デング熱やジカウイルスのような ウイルスにも当てはまります
結論:
- HAP2は膜融合を媒介する保存されたメカニズムを表しています.
- この発見は,細胞とウイルスの膜融合機構の共通の進化的起源を示唆している.
- HAP2は生殖生物学と感染症における治療的介入の標的として機能する.
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