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アデノシンA1受容体の構造は,サブタイプ選択性の基礎を明らかにする

Alisa Glukhova1, David M Thal1, Anh T Nguyen1

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Cell
|February 25, 2017
PubMed
まとめ

研究者らは,薬剤に結合するアデノシンA1受容体 (A1-AR) の結晶構造を明らかにし,選択的標的化を可能にするユニークな特徴を発見した. この発見は様々な病気に対する新しい治療法の開発に役立ちます.

キーワード:
Gタンパク質結合受容体アデノシンアロステリック調節心血管疾患クリスタルグラフィードラッグデザイン薬物の発見イシュケミア-再輸神経疾患の痛み構造生物学

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