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Updated: Mar 7, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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多価小分子汎RAS阻害剤

Matthew E Welsch1, Anna Kaplan2, Jennifer M Chambers2

  • 1Department of Chemistry, Columbia University, New York, NY 10027, USA.

Cell
|February 25, 2017
PubMed
まとめ

研究者はRASタンパク質を標的にする新しい小分子を開発し,臨床前モデルで抗腫瘍活性を示しました. このパン-RAS阻害剤は新しいがん治療戦略として潜在性を示しています.

キーワード:
GTPーゼについてハラスクラスNRA についてラス癌について化学生物学ドラッグデザインマルチバレンツ小分子

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