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ミトコンドリアに誤った折りたたまれたタンパク質をインポートすることにより,細胞細胞タンパク質静止

Linhao Ruan1,2, Chuankai Zhou3, Erli Jin2

  • 1Center for Cell Dynamics, Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, Maryland 21205, USA.

Nature
|February 28, 2017
PubMed
まとめ

誤った折り畳まれたタンパク質は,分解のためにミトコンドリアに輸入され,その過程はMAGIC (サイトゾールの守護者としてのミトコンドリア) と呼ばれる. このメカニズムは老化と神経変性における タンパク質集積とミトコンドリアの健康管理に役立ちます

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