高齢男性におけるテストステロン治療と認知機能 テストステロンの低下と年齢に関連する記憶障害
Susan M Resnick1, Alvin M Matsumoto2, Alisa J Stephens-Shields3
1Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
JAMA
|February 28, 2017
まとめ
テストステロン治療は,年齢に関連した記憶障害と低テストステロンレベルを持つ高齢者の記憶や認知機能を改善しませんでした. この研究では,プラセボと比較して1年間,有意な差異は認められませんでした.
科学分野:
- ゲロントロジー
- 神経科学
- 内分泌学
背景:
- 認知機能は 老化とともに衰えていくことが多いのです
- 以前の研究では テストステロンの治療は 認知能力を高めると示唆されていました
- 年齢関連の記憶障害 (AAMI) は,テストステロンが低い多くの高齢者に影響します.
研究 の 目的:
- テストステロン療法が 言語記憶やその他の認知機能を 改善するかどうかを調べるため
- 低テストステロンとAAMIを持つ高齢者のテストステロン治療とプラセボを比較する
主な方法:
- ランダム化され,プラセボ対照試験で,低テストステロンとAAMIを有する65歳以上の493人の男性を対象とした.
- 参加者は1年間毎日テストステロンゲルまたはプラセボゲルを投与された.
- 認知機能は,言語記憶,視覚記憶,実行機能,空間能力のテストを使用して,ベースライン,6ヶ月および12ヶ月で評価されました.
主要な成果:
- テストステロン治療は,プラセボと比較して,遅れた段落の記憶 (言語記憶) の有意な改善を示さなかった.
- 視覚記憶,実行機能,または空間的能力において,グループ間の有意な差異は観察されなかった.
- 12ヶ月の研究期間中,遅れた段落の記憶の平均スコアは両グループで同じでした.
結論:
- 1年間のテストステロン治療は,低テストステロンとAAMIを持つ高齢者の記憶や認知機能を向上させなかった.
- テストステロンの治療は 老化に伴う認知機能低下を 改善するのに効果的ではないことが 示唆されています
- 高齢男性における認知障害に対する他の潜在的な介入を探るには,さらなる研究が必要になるかもしれません.
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