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Updated: Mar 7, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

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ダブルブラインドおよびオープンラベルの延長試験による6000人以上の患者におけるエヴォロキュマブの安全性分析

Peter P Toth1, Olivier Descamps2, Jacques Genest2

  • 1From CGH Medical Center, Sterling, IL, and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.); Lipid Clinic, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium (O.D.); The McGill University Health Centre, Montreal, Canada (J.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK (N.S.); Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK (D.P.); and Amgen Inc, Thousand Oaks, CA (R.D., C.D., Y.W., M.G., M.U., R.S., S.M.W.). peter.toth@cghmc.com.

Circulation
|March 3, 2017
PubMed
まとめ

臨床試験では,PCSK9阻害剤であるエヴォロキュマブが,対照群と比較して同様の安全性と耐性を示した. この6000人以上の患者の分析は,コレステロール管理のための好ましい利益リスクプロフィールを裏付けています.

キーワード:
モノクローン抗体コレステロール,LDL長期にわたる有害事象筋痛プロプロテインコンバーターゼ9

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