関連する実験動画

Updated: Mar 6, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

8.0K

Notch-Jagged複合構造は,リガンドのセンシビリティの調節にキャッチボンドを伴う

Vincent C Luca1,2, Byoung Choul Kim3,4, Chenghao Ge5

  • 1Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|March 4, 2017
PubMed
まとめ

ノッチ受容体の活性化には,機械的な力とグリコシル化が不可欠である. 新しい構造データは,Notch1に結合するJagged1が,細胞の運命を決定するためにこれらの力をどのように使用しているかを明らかにしています.

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