活発な覚醒中の新皮質の樹状阻害の層特異的な調節
William Muñoz1, Robin Tremblay1, Daniel Levenstein1,2
1Neuroscience Institute and Department of Neuroscience and Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
まとめ
脳内のソマトスタチンを発現する内ニューロンは,覚醒中に反対の活動変化を示し,層特有の阻害を明らかにします. これは,新皮質の dendritic 信号伝達を制御する cholinergic と VIP 内ニューロンの活動を強調します.
科学分野:
- 神経科学
- 細胞神経科学
- システム神経科学
背景:
- γ-アミノバター酸 (GABA) 活性インプットは,ピラミッド細胞におけるシナプス統合を調節する.
- 行動中のGABAergicインプットの空間時間的ダイナミクスはよく理解されていません.
研究 の 目的:
- 行動するマウスにおけるソマトスタチン発現 (Sst) 内ニューロンの層特異的調節を調査する.
- 血管活性性腸ペプチド (Vip) インターニューロンとSstインターニューロンの活性におけるコレリン調節の役割を理解する.
主な方法:
- Sst 内神経を記録し,標識するために,光学標識と電気生理学を使用した.
- 行動するマウスで実験を行った.
主要な成果:
- 異なる皮質層の内部ニューロンのサブタイプは,活発な覚醒への移行中に反対の活動変化を示した.
- Sstインターニューロンの活動は,Vipインターニューロン媒介の阻害とコレリン誘導により調節された.
- 異なるSstインターニューロンのサブタイプは,補完的なラミナールドメインを神経化する.
結論:
- 内部ニューロン媒介の抑制は,層特異的な方法で行動状態によって調節される.
- これは哺乳類の新皮質における dendritic 信号伝達の 分割された調節に洞察を与えます
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