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Assaying for Inorganic Polyphosphate in Bacteria
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古代 の リン酸 の ない 代謝 の 残留物
Joshua E Goldford1, Hyman Hartman2, Temple F Smith3
1Bioinformatics Program, Boston University, Boston, MA 02215, USA.
Cell
|March 7, 2017
まとめ
単純なプリバイオティック化合物とチオエステルを使用した,リン酸塩のない代謝は,現代の生化学に先立ちました. この発見は生命の新たな起源を示唆し 初期の代謝における リン酸塩の重要な役割に 異議を唱えます
科学分野:
- 生命 研究 の 起源
- システム生物学
- 前生物化学
背景:
- 生命にとって重要ですが 初期の地球での地化学的存在は議論の余地があります
- 主な代謝経路の起源とそのリン酸への依存は不明である.
研究 の 目的:
- プロトメタボリズムは,リン酸の組み込み前に出現するかもしれないという仮説を調査する.
- リン酸から独立した代替代謝ネットワークを探求する.
主な方法:
- システム生物学のアプローチが採用されました.
- 謎めいた,リン酸依存の代謝ネットワークの分析
主要な成果:
- 単純なプレバイオティック化合物から生成される,リン酸に依存しないコア代謝が特定された.
- このネットワークは重要な生物分子の 生体合成をサポートし 鉄と硫黄のクラスターを好む.
- チオエステル結合は,リン酸結合よりも熱力学的ボトルネックを効果的に克服します.
結論:
- 特定されたネットワークは,早期の無リン酸生化学の代謝化石を表す可能性があります.
- これは,チオエステルベースの代謝がリン酸とRNAより前の提案を支持する.
- 生命の起源の 可能性のある別の経路を示唆しています
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