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Updated: Mar 6, 2026

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
Published on: October 31, 2017
プラズマセラミド,地中海食,およびPREVENCIÓN CON DIETA MEDITERRÁNEA試験における心血管疾患の発生
Dong D Wang1, Estefanía Toledo1, Adela Hruby1
1From Department of Nutrition (D.D.W., W.C.W., Q.S., Y.Z., M.G.-F., C.-H.L., F.B.H.); Department of Epidemiology (D.D.W., W.C.W., L.L., F.B.H.), Department of Biostatistics (B.A.R., L.L.), Department of Genetics and Complex Diseases (C.-H.L.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition (M.A.M.-G.), Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (E.T., C.R., M.R.-C., M.A.M.-G.); Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (E.T., C.R., M.R.-C., M.A.M.-G.); CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain (E.T., C.R., M.R.-C., D.C., M.F., R.E., E.R., J.L., M.F., F.A., L.S.-M., J.S.-S., M.A.M.-G.); Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Tufts University Friedman School of Nutrition Science and Policy, Boston, MA (A.H.); Channing Division for Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (B.A.R., W.C.W., Q.S., F.B.H.); Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili, Rovira i Virgili University, Reus, Spain (M.G.-F., J.S.-S.); Department of Preventive Medicine, University of Valencia, Spain (D.C.); Department of Preventive Medicine, University of Málaga, Spain (E.G.-G.); University Institute of Health Sciences (IUNICS), University of Balearic Islands and Hospital Son Espases, Palma de Mallorca, Spain (M.F.); Department of Internal Medicine (R.E.), Lipid Clinic, Department of Endocrinology and Nutrition Institut d'Investigacions Biomediques August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Spain (E.R.); Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain (J.L.); Cardiovascular and Nutrition Research Group, Institut de Recerca Hospital del Mar, Barcelona, Spain (M.F.); Department of Cardiology, University Hospital of Alava, Vitoria, Spain (F.A.); Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Spain (L.S.-M.); and Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA (C.B.C.).
血のセラミド濃度の高さは,心血管疾患 (CVD) のリスクの増加と関連しています. 地中海の食事の介入はこれらのリスクを軽減し,セラミドとCVDに対する保護的な食事効果を示唆します.
科学分野:
- メタボロミクス
- 心血管疾患の研究
- 栄養学的流行病学
背景:
- 新興の証拠は,セラミドが過剰栄養と心血管疾患 (CVD) の病理と関連していることを示唆しています.
- 以前の研究は,実験室内,動物モデル,または小規模な臨床集団に限られていた.
- プラズマセラミドとCVDリスクを調査する前向きな研究は欠けていた.
研究 の 目的:
- 血セラミド濃度とCVDリスクとの関連を将来的に調査する.
- 地中海ダイエットによる介入が この関連性を変化させるかどうかを調べる
主な方法:
- PREDIMED試験 (n=980) のケース・コホート研究で,230例のCVD症例が報告されました.
- 液体染色体タンデム質量測定法で測定された血セラミド濃度
- セラミドとCVDリスクの関連性を分析した.
主要な成果:
- 特定のセラミドの血濃度の上昇 (C16: 0 , C22: 0 , C24: 0 , C24: 1) は,CVDのリスクが著しく高かった.
- 複合セラミドスコアは,極端な四分位数全体で心血管疾患のリスクが2. 18倍増加したことを示した.
- セラミドスコアとCVDリスクとの関連は,食事グループによって有意に変化した.
結論:
- 血のセラミド濃度は,CVDの発生と正に関連しています.
- 地中海食の介入は,高血セラミドが心血管疾患のリスクに与える有害な影響を軽減する可能性があります.
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