ストロマGli2活動は,乳頭上皮幹細胞のニッチシグナルプログラムを調整する

Chen Zhao^1,2, Shang Cai¹, Kunyoo Shin^1,2,3

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)

|March 11, 2017

まとめ

乳腺幹細胞のニッチは,ホルモンに反応するために,ストロマ細胞のGli2を必要とします. 幹細胞の欠陥だけでなくニッチ機能障害も乳房の成長障害を引き起こす可能性があります

科学分野:

発達生物学
幹細胞生物学
内分泌学

背景:

幹細胞のニッチは臓器の維持と再生に不可欠です
乳腺幹細胞はホルモンの信号に反応する特殊な微小環境を必要とします
ヘッジホッグ経路は発達中の重要な信号経路です

研究の目的:

乳腺幹細胞ニッチにおけるヘッジホッグ経路エフェクターであるGli2の役割を調査する.
乳腺のニッチがホルモンの調節にどう反応するかを理解する
ニッチ機能障害と乳房成長障害の関連を調べる

主な方法:

マウスモデルを使って乳腺幹細胞のニッチを研究した
Gli2の発現と下流の標的を調査した
Gli2のストロマ細胞における役割と,上皮幹細胞との相互作用を分析した.
Gli2によるホルモン受容体の調節を調べた

主要な成果:

乳腺のストロマ細胞のGli2は,ホルモンに反応するニッチシグナルプログラムをオーケストラします.
Gli2は上皮の幹細胞とホルモン受容体 (エストロゲン,成長ホルモン) を調節する因子を活性化させます.
Gli2によって媒介されるニッチ機能障害は,乳房成長の病原化につながる可能性があります.

結論:

Gli2は機能的な乳腺幹細胞のニッチに不可欠です.
ニッチ機能障害は幹細胞の欠陥に加えて人間の病気にも寄与します
発見は,ホルモン欠乏症に関連するものを含め,乳房成長障害を理解するための意味を示唆しています.

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