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Updated: Mar 6, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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病原性EPO変異によって明らかになったサイトカインシグナル伝達における機能的選択性

Ah Ram Kim1, Jacob C Ulirsch1, Stephan Wilmes2

  • 1Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|March 12, 2017
PubMed
まとめ

エリトロポエチン (EPO) の突然変異は,正常に近い受容器親和性にもかかわらず,受容体結合と下流信号伝達を変化させ,重度の貧血を引き起こす. この発見は,バイアスなサイトカインシグナル伝達に関連した治療可能な貧血を特定します.

キーワード:
JAK2 についてサイトカインエリトロポエシスエリトロポエチン機能的選択性ヘマトポエシスレセプターシグナリング

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