心血管疾患に対するポリピルの使用と現在の証拠
Mark D Huffman1, Denis Xavier2, Pablo Perel3
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lancet (London, England)
|March 15, 2017
まとめ
ポリピル (複数錠の薬) は 動脈硬化症の予防に 有望な効果を示しています 動脈硬化症の予防に 有望な効果を示しています 臨床結果への影響を確認し,実施を導くためにさらなる研究が必要である.
科学分野:
- 心血管医学
- 薬理学について
- 公衆衛生
背景:
- ポリピルは30カ国以上で承認されていますが,他の疾患に対する固定用量組み合わせと比較して,世界的な使用とデータが限られています.
- 動脈硬化症の予防に応用するには,さらなる研究と臨床指導が必要です.
研究 の 目的:
- 将来の研究と臨床実践におけるポリピルの使用ガイドを提案する.
- 異なる集団と指示を考慮して,動脈硬化症の予防のためのポリピルの証拠を合成する.
主な方法:
- 32カ国の9059人の参加者を対象とした13件のポリピル試験のレビュー.
- 集団によるポリピル使用の分類 (二次予防,高リスクプライマリ予防,集団治療) と indikacion (開始,ステップアップ,置換).
主要な成果:
- ポリピルは通常 薬の服用を良くし 耐性も良好です
- 心血管疾患の危険因子のレベルを 効果的に低下させていますが 異質性は確実性に影響します
- 現在の試験では,標準治療と比較して,臨床結果の有意な差異は示されていない.
結論:
- ポリピル治療は 動脈硬化による早死率を減らすための 拡張可能な戦略です
- 順守とアクセスの改善は重要な利点ですが,最適な実施にはさらなるデータと臨床経験が必要です.
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