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自閉症遺伝子Ube3aと発作は,VTA Cbln1を抑制することで,社交性を損なう

Vaishnav Krishnan1, David C Stoppel1,2,3, Yi Nong1,2

  • 1Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02115, USA.

Nature
|March 16, 2017
PubMed
まとめ

母親の15q11-13重複は,Cbln1をダウンレギュレーションすることによって,UBE3Aを増加させ,社交性に影響を与える. 発作は自閉症に関連したこれらの欠陥を悪化させ,VTAグルタミン酸ニューロンを標的にすることで逆転させることができます.

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