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抗癌スルフォナミドは,DCAF15へのリクルートを通じてRBM39の分解を誘導することによってスプライシングを標的とする

Ting Han1, Maria Goralski2, Nicholas Gaskill2

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|March 18, 2017
PubMed
まとめ

インジスラムの抗がん剤は,RNA結合モチーフタンパク質39 (RBM39) を標的とし,CUL4- DCAF15複合体を通して分解し,mRNA前スプライシングに影響を与えます. DCAF15の発現レベルは,インジスラムおよび関連SPLAM薬に対する癌細胞の感受性と相関しています.

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