炎症は,サルモネラ種間の細菌移転を促進する
Médéric Diard1, Erik Bakkeren2, Jeffrey K Cornuault3
1Institute of Microbiology, ETH Zurich, Switzerland. mederic.diard@micro.biol.ethz.ch wolf-dietrich.hardt@micro.biol.ethz.ch.
Science (New York, N.Y.)
|March 18, 2017
まとめ
腸の炎症は 細菌菌の伝播を促し 細菌の毒性を高めます 粘膜ワクチンによる炎症の予防は この病原体の進化を阻害し 感染症に対する新しい戦略を提供します
科学分野:
- 微生物学
- 遺伝学
- 進化生物学
背景:
- バクテリオファージの移転,またはリソジェニック変換は,細菌の毒性の進化の重要な原動力です.
- 宿主環境内の溶解性変換ダイナミクスを支配する要因は,まだ十分に理解されていません.
研究 の 目的:
- サルモネラ・ティフィムリウム菌株間のSopEΦプロファージ移転のダイナミクスをマウスモデルで調査する.
- 宿主の炎症がバクテリオファージの移転を媒介し,バクテリアの進化に与える影響を明らかにする.
主な方法:
- サルモネラ・ティフィムリウムによるマウスの下痢モデルを用いて,プロファージの移転を研究した.
- 誘発性腸内炎症の条件下における量化されたリゾジェニック変換率
- 炎症,SOS反応,ファグの抗抑制表現を結びつける分子メカニズムを分析した.
主要な成果:
- 腸の炎症と腸内疾患は,サルモネラ・ティフィムリウムで3日以内にSopEΦの伝達が有意に増加した (> 55%).
- 炎症の欠如は,SopEΦの転送を最大10 ^ 5倍に減少させた.
- 炎症誘発のSOS応答と腫瘍抗抑制剤の発現は,ファグの移転を促進するために重要であると特定されました.
結論:
- 宿主誘発の炎症は,細菌移転と細菌の毒性の進化を促進する重要な要因である.
- 粘膜ワクチン接種は炎症を予防し,それによってプロファージ移転を廃止し,一般化可能な戦略を示唆した.
- 病原体の進化を制御する新しい方法として 病原体によるファグの移転をターゲットにすることがあります
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