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男性から女性へのトランスジェンダーの乳がん. ケースレポート ケースレポート
T J Pritchard1, D A Pankowsky, J P Crowe
1Department of Surgery, University Hospitals, Cleveland, OH 44106.
JAMA
|April 15, 1988
まとめ
このレポートは,トランスジェンダー女性の乳がんの希少な症例について,トランスジェンダー女性への移行から10年後の詳細を述べています. 文書化されている限られた事例を強調し,エストロゲンについて論じています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 腫瘍学 腫瘍学
- ジェンダー・アファメーション・ケア
背景:
- 乳がんは男性ではまれである.
- トランスジェンダーの女性は,ホルモン置換療法 (HRT) を使用することができます.
- ガンリスクに対するHRTの長期的な影響については,調査が必要です.
研究 の 目的:
- 男性から女性へのトランスジェンダー患者の乳がんの症例を報告するために.
- トランスジェンダーの男性における乳がんに関する既存の文献をレビューする.
- 乳がんの病因学におけるホルモン療法の潜在的な役割について議論する.
主な方法:
- ケースレポートのプレゼンテーション.
- 同様のケースに関する文献レビュー.
- ホルモンの影響に関する議論.
主要な成果:
- 乳がんの症例は,男性から女性への性転換から10年後に発生した.
- トランスジェンダーの男性における乳がんの先例は2例しか確認されなかった.
- 報告されたすべての症例は,経口エストロゲンの長期使用を伴う.
結論:
- 乳がんは,トランスジェンダーの女性では珍しいが可能な診断です.
- 長期にわたるエストロゲン療法が原因になる可能性があります.
- 男性の乳がんにおけるホルモンの影響に関するさらなる研究が必要である.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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