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Updated: Mar 5, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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非リボソームイミン自然産物によるペプチドマクロサイクリング

Lara R Malins1, Justine N deGruyter1, Kevin J Robbins2

  • 1Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|March 23, 2017
PubMed
まとめ

この研究では,ペプチドマクロサイクリングのための新しい熱力学的方法が導入され,ペプチドイミンから水中のグループを保護せずに多様なマクロサイクルを生成します. このアプローチは,複雑なサイクルペプチドと天然製品類の合成を簡素化します.

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