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Updated: Mar 5, 2026

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抗原表現プロファイリングはリンパ腫の免疫グロブリン新抗原の認識を明らかにする

Michael S Khodadoust1, Niclas Olsson2, Lisa E Wagar3

  • 1Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.

Nature
|March 23, 2017
PubMed
まとめ

研究者はリンパ腫腫瘍に特異的なネオアンチゲンを特定し,主に免疫グロブリン領域から発生した. これらの免疫グロブリン由来ネオアンチゲンは,T細胞によって有効なリンパ腫免疫療法のために標的とすることができる.

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Antigens Involved in Adaptive Immunity

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T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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