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γδ T細胞はアンジオテンシンII誘発の高血圧と血管損傷を媒介する

Antoine Caillon¹, Muhammad Oneeb Rehman Mian¹, Julio C Fraulob-Aquino¹

¹From Lady Davis Institute for Medical Research (A.C., M.O.R.M., J.C.F.-A., K.-G.H., T.B., S.O., P.P., E.L.S.), Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital (E.L.S.), McGill University, Montréal, Québec, Canada; and Universitaire Ziekenhuizen Leuven Gasthuisberg, University of Leuven, Belgium (P.R.S.).

|March 24, 2017

まとめ

ガンマデルタT細胞は,アンジオテンシンII誘発の高血圧,血管損傷,T細胞活性化において重要な役割を果たします. これらの発見は,ガンマデルタT細胞がヒトの高血圧発症に寄与する可能性があることを示唆している.

科学分野:

免疫学
心血管科学

背景:

高血圧の発達には,先天的な抗原を提示する細胞と適応性T細胞が含まれます.
高血圧の病理学に寄与する特定のTリンパ球サブセットは完全に理解されていません.
生まれながらのガンマ・デルタ・T細胞 (TCR) は高血圧で免疫反応を起こす可能性があります.

研究の目的:

ガンマデルタT細胞がアンジオテンシンII誘発性高血圧における役割を調査する.
ガンマ・デルタ・T細胞欠乏が高血圧,血管損傷,T細胞活性化に影響するかどうかを判断する.
ガンマ・デルタ・T細胞とヒトの高血圧の関連性を調べる

主な方法:

ガンマ・デルタ・T細胞が枯渇した野生型とTcrδ-/-型のマウスを用いて,3日,7日または14日間Ang IIを注入した.
フロー・サイトメトリーによるT細胞プロファイルの評価,テレメトリーによるシストリック血圧 (SBP),圧縮筋膜撮影による中枢動脈内皮機能の評価.
TCRガンマ定数領域の遺伝子発現とヒトのマイクロアレイ研究から得られた臨床データ.

主要な成果:

ガンマ・デルタ・T細胞の数と活性化が野生型のマウスで増加した.
ガンマ・デルタ・T細胞枯渇したTcrδ-/ - マウスでは,Ang II誘発の高血圧と内皮機能障害が取り消された.
ガンマ・デルタ・T細胞の欠乏は,Ang II誘発のT細胞の活性化を鈍化させた.
人間におけるSBPとガンマデルタT細胞との間に有意な関連性が見つかりました.

結論:

ガマデルタT細胞は,Ang II誘発の高血圧,血管損傷,T細胞活性化の主要な媒介である.
ガンマ・デルタ・T細胞は,ヒトの高血圧の発生に潜在的に寄与していると考えられています.

キーワード:

アンジオテンシンII 血圧免疫システム血管生物学 γδ T細胞

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