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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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リソソームのコレステロールは,SLC38A9-ニーマン・ピックC1信号複合体を通してmTORC1を活性化させる

Brian M Castellano1,2, Ashley M Thelen1,2, Ofer Moldavski1,2

  • 1Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|March 25, 2017
PubMed
まとめ

重要な成長栄養素であるコレステロールは,ライソソームにおけるラパミシン複合体1 (mTORC1) の機械的標的を活性化します. このプロセスにはSLC38A9-NPC1複合体が関与し,リゾソームのコレステロールと細胞の成長シグナルを結びつける.

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