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Updated: Mar 5, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
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PGC-1αの選択的化学阻害 グルコネオゲン活性 2型糖尿病を改善する

Kfir Sharabi1, Hua Lin2, Clint D J Tavares1

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|March 25, 2017
PubMed
まとめ

研究者らは,PGC-1αアセチル化を標的とした小分子SR-18292を特定し,グルコースの産生を減少させた. この新しいアプローチは,グルコースホメオスタシスとインスリン感受性を改善することによって,タイプ2型糖尿病 (T2D) の治療に希望を示しています.

キーワード:
アルファリーサGCN5 についてPGC-1アルファ薬物の発見グルカゴングルコネオゲネシス肝臓のグルコース生成インスリン抵抗性タンパク質アセチル化2型糖尿病

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