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Updated: Mar 5, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
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ヒトのエピスタティック相互作用はIL7Rスプライシングを制御し,多発性硬化症のリスクを増大させる

Gaddiel Galarza-Muñoz1, Farren B S Briggs2, Irina Evsyukova3

  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Center for RNA Biology, Duke University, Durham, NC 27710, USA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Cell
|March 25, 2017
PubMed
まとめ

研究者は,多発性硬化症 (MS) のリスクに影響を与えるインタールイキン-7受容体α (IL7R) の主要な調節体としてDDX39Bを特定しました. DDX39Bの遺伝子変異は,IL7Rエクソン6のスプライシングに影響することで,MSの感受性に影響します.

キーワード:
DDX39B についてIL7R について代替スプライシング自己免疫疾患エピスタシス遺伝子関連多発性硬化症

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