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Updated: Jul 20, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
09:49

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 13, 2010

ゲルムラインのIgガンマ2bトランスクリプトのミトゲンおよびIL-4調節された発現:指向的な重鎖クラスのスイッチングの証拠

S Lutzker1, P Rothman, R Pollock

  • 1Howard Hughes Medical Institute, Columbia University, New York, New York 10032.

Cell
|April 22, 1988
PubMed
まとめ

バクテリアのリポポリサッカリド (LPS) とリンフォカインIL-4は,B細胞における免疫グロブリン遺伝子のスイッチングに影響を与えます. LPSは生殖線ガンマ2b転写を活性化し,IL-4はこのプロセスを阻害し,B細胞クラスの切り替えを調節する.

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