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Updated: May 2, 2026

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

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左心室機能障害は,メセンキマストロマ細胞を炎症性フェノタイプに切り替えて,トール型受容体-4経由で修復特性を損なう

Nili Naftali-Shani1, La-Paz Levin-Kotler1, Dahlia Palevski1

  • 1From Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Israel (N.N.-S., L.-P.L.-K., D.P., U.A., D.K., N.L., J.L.); Tamman Cardiovascular Research Institute, Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, Israel (N.N.-S., L.-P.L.-K., D.P., U.A., D.K., N.L., J.L.); Sheba Center for Regenerative Medicine, Stem Cell and Tissue Engineering, Tel-Hashomer, Israel (N.N.-S., L.-P.L.-K., D.P., U.A., D.K., N.L., J.L.); and Cardiac Research Laboratory, Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Rabin Medical Center, Tel-Aviv University, Petah Tikva, Israel (E.H.).

Circulation
|March 31, 2017
PubMed
まとめ

左心室機能不全 (LVD) は,心筋内膜細胞 (MSC) の炎症を促進し,その修復能力を阻害する. MSCにおけるトール型受容体4 (TLR4) 欠乏症は,心臓損傷における生存率と治療効果を改善する.

キーワード:
心不全炎症メゼンキマ・ストロマル/幹細胞トール型受容体-4

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