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肺動脈高血圧における血管内膜成長因子受容体3による内膜骨形態遺伝タンパク質受容体2型活性調節

Cheol Hwangbo1, Heon-Woo Lee1, Hyeseon Kang1

  • 1From Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (C.H., H.-W.L., H.K., H.J., I.P., J.H., J.-D.K., W.P.D., X.H., S.L., O.E.-H., A.S., H.J.C., S.-W.J.); Department of Biology, University of North Carolina, Chapel Hill (D.S.W., V.L.B.); School of Life Sciences and Cell Logistics Research Center, Gwangju Institute of Science and Technology, Korea (B.P., S.-W.J.); Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, OH (L.P., S.C., S.C.E.); Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul (E.M.H., J.-Y.P.); School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul (J.-Y.P.); Department of Neurology, Yale University School of Medicine, New Haven, CT (J.-L.T.); and Université Pierre and Marie Curie-Paris 6, CRICM, Groupe Hospitalier Pitié-Salpètrière, France; INSERM, UMRS 975, Groupe Hospitalier Pitié-Salpètrière, Paris, France; APHP, Groupe Hospitalier Pitié-Salpètrière, Paris, France (J.-L.T.).

Circulation
|March 31, 2017
PubMed
まとめ

血管内皮成長因子受容体3 (VEGFR3) は,骨型変異性タンパク質受容体2 (BMPR2) のシグナル伝達を調節し,肺動脈高血圧 (PAH) の発生に影響する. PAH細胞におけるVEGFR3の回復により,BMPシグナル伝達が改善され,PAHの重要な要因としてVEGFR3が特定されました.

キーワード:
ヒトのFLT4タンパク質骨形態遺伝タンパク質受容体II型内皮細胞肺高血圧

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