関連する実験動画

Updated: May 3, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

14.0K

P2X7 欠乏症は病変性炎症体活動を阻害し,マウスの動脈硬化を改善する

Peter Stachon1, Adrian Heidenreich2, Julian Merz2

  • 1From Department of Cardiology and Angiology I, Heart Center Freiburg University, Germany (P.S., A.H., J.M., I.H., D.W., F.W., S.v.G., P.A., C.H., N.H., J.R., C.v.z.M., C.B., A.Z.); and Faculty of Medicine (P.S., A.H., J.M., I.H., D.W., F.W., S.v.G., P.A., C.H., N.H., J.R., C.v.z.M., C.B., M.I., A.Z.) and Faculty of Biology (J.M.) and Department of Pneumology (N.E., M.I.), University of Freiburg, Germany. peter.stachon@universitaets-herzzentrum.de.

Circulation
|April 6, 2017
PubMed
まとめ

純粋性受容体P2X7 (P2X7) 軸は炎症体の活性化と動脈硬化に重要な役割を果たします. P2X7のシグナル伝達を遮断すると,プラークの炎症と実験的な動脈硬化が減少し,P2X7が潜在的な治療標的であることを示唆する.

キーワード:
P2X7 について動脈硬化症炎症ゾーム炎症マクロファージ

さらに関連する動画

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.3K
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.7K

関連する概念動画

Inflammation01:38

Inflammation

Overview
46.6K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
659