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アンジオテンシンII受容体の選択性と多様性の構造的基礎

Haitao Zhang1,2, Gye Won Han1, Alexander Batyuk3

  • 1Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA.

Nature
|April 6, 2017
PubMed
まとめ

血管新生素II受容体の構造に関する洞察は,AT2Rの機能が不明であることを明らかにする. AT2RにおけるヘリックスVIIIのユニークな位置づけは,活性化状態を安定させながらも,シグナル伝達を妨げ,その独特な役割を説明し,新しい薬剤設計を導く.

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