![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
移行金属で触媒化されたアルキル-アルキル結合形成:クロスカップリング化学のもう一つの次元
1Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|April 15, 2017
まとめ
有機合成では,炭素と炭素の結合を効率的に構築することが不可欠です. トランジション金属触媒によるクロスカップリングの最近の進歩には,アルキル電ophiles が含まれており,分子多様性を拡大し,エナチオコンバージェント反応を可能にします.
科学分野:
- 有機化学
- 合成化学
- カタリシス
背景:
- 炭素と炭素の結合は有機分子の骨格を形成する.
- 移行金属で触媒化されたクロスカップリング反応は,C−C結合形成の強力なツールである.
- 伝統的な方法は主にアリルまたはアルケニル電極を用いた.
研究 の 目的:
- 新しいクロスカップリングの方法の開発を強調する.
- アルキル電ophilesを含むクロスカップリングの拡張を表示する.
- これらの新しい方法によって提供される ステレオ化学的制御を強調する.
主な方法:
- 新しい移行金属触媒のクロスカップリング反応の開発.
- アルキルエレクトロフィルをカップリングパートナーとして利用する.
- エナチオコンバージェント結合を研究する
主要な成果:
- アルキルエレクトロフィルの交互結合のための多用途な新しい方法が確立されています.
- アクセシブルな標的分子の多様性の 顕著な拡大
- ステレオ化学制御を強化するエナチオコンバージェントカップリングの導入
結論:
- アルキルエレクトロフィールを含むクロスカップリング反応は,有機合成を大幅に進歩させた.
- これらの方法は,より幅広い複雑な有機分子へのアクセスを提供します.
- エナチオコンバージェントカップリングを行う能力は,クロスカップリングプロセスの有用性を大幅に高める.
関連する概念動画
03:45Formation of Complex Ions
18.8K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
18.8K
02:51Metal-Ligand Bonds
19.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
19.3K
01:23Properties of Organometallic Compounds
2.1K
Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
2.1K
01:23Complexation Equilibria: Overview
1.6K
Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...
The equilibrium constant of the complexation reaction is represented as the formation constant...
1.6K
01:19Complexation Equilibria: The Chelate Effect
1.7K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.7K
01:22Heterogeneous Catalysis
141
Heterogeneous catalysis involves a catalyst in a different phase from the reactants. It is a process where the catalyst and the reactants are in distinct phases, typically solid and gas or liquid.Most heterogeneous catalysts are metals, metal oxides, or acids. The list includes transition metals like iron (Fe), cobalt (Co), nickel (Ni), palladium (Pd), platinum (Pt), chromium (Cr), manganese (Mn), tungsten (W), silver (Ag), and copper (Cu). These metals possess partially vacant d orbitals that...
141