鞭状駆動軸のナノスケール長さの制御は,固定された外膜を打つ必要があります

Eli J Cohen¹, Josie L Ferreira², Mark S Ladinsky³

¹Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

Science (New York, N.Y.)

|April 15, 2017

まとめ

バクテリアの鞭棒の組み立ては,周回プラズマ空間の幅によって制限されます. ブラウンの脂質タンパク質は,この幅を調節し,適切な鞭状構造と細菌の運動機能を保証します.

科学分野:

微生物学
分子生物学
バイオ物理学

背景:

細菌の鞭毛は運動に不可欠な複雑な分子機構です
鞭状の構成要素の適切な組み立ては,機能に極めて重要であり,その偏差は,身体学的悪影響をもたらす.
重要な構成要素である鞭棒は約25ナノメートルの正確な長さで自己組織化されます

研究の目的:

バクテリアの鞭棒の長さを制限する規制メカニズムを調査する.
棒の組み立ての制限における周回プラズマ空間幅の役割を決定する.
プラズマ周りの次元を調節するブラウンの脂質タンパク質の機能を解明する.

主な方法:

変異した周回プラズマ空間を持つバクテリア変異体における鞭状の組成を調べた.
鞭棒の長さと周回プラズマの幅を測定するために生体物理的技術を使用した.
ブラウン脂質の外部膜結合と周回プラズマ構造への貢献を分析した.

主要な成果:

フラゲラ棒の長さは,内膜と外膜の間の周回プラズマ空間幅によって直接制限されます.
ブラウン脂質の長さは,周回プラズマの幅を決定する重要な要素です.
ブラウンの脂質タンパク質の長さを変化させると,外側の膜の結合と,その後の棒の組成に影響する.

結論:

ブラウン脂質によって調節される周回プラズマ空間幅は,バクテリアの鞭棒の自己組み立てのための重要な物理的制約として作用する.
このメカニズムは,機能的なフラジェラトルク伝送に必要な正確な寸法を確保します.
バクテリアの細胞封筒の構造は,鞭のような外部毒性の要因の組み立てと機能と密接に関連しています.

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