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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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モリブデン複合体から化学的に無害なリガンドによるアンモニア活性化,H2の進化と窒素形成

Grant W Margulieux1, Máté J Bezdek1, Zoë R Turner1

  • 1Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.

Journal of the American Chemical Society
|April 18, 2017
PubMed
まとめ

モリブデン複合体とビスイミノピリジンリガンドはアンモニアを活性化し,二水素を形成し,末端ニトリドの合成を可能にします. この研究は,新しい二重アンモニア活性化経路を明らかにしています.

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Nitriles are reduced to amines in the presence of strong reducing agents like lithium aluminum hydride through a typical nucleophilic acyl substitution. The reaction requires two equivalents of the reducing agent. The reducing agent acts as a source of hydride ions.
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The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
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