新生児がクロストリディア種を取得すると,細菌の病原体によるコロニー化から保護されます
Yun-Gi Kim1,2, Kei Sakamoto3,2, Sang-Uk Seo3,2
1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. gabriel.nunez@umich.edu yungikim77@gmail.com.
Science (New York, N.Y.)
|April 22, 2017
まとめ
新生児のマウスは 病原体に対する腸内微生物群の保護が欠けています 乳児の免疫における重要な役割を強調します 乳児の免疫は
科学分野:
- 微生物学
- 免疫学
- 胃腸内科
背景:
- 新生児は感染症に敏感で 免疫系が未成熟であることが多い
- この脆弱性の背後にある正確なメカニズムと腸内微生物群の役割は まだ十分に理解されていません
研究 の 目的:
- 新生児の細菌病原体に対する耐性における腸内微生物の組成の役割を調査する.
- 生命の初期に保護を担う特定の細菌分類を特定する.
主な方法:
- 新生児と成人のマウスの腸内微生物群との成体無菌マウスのコロニー化.
- 新生児死亡の原因となる 特定の細菌の病原体で コロニー化されたマウスを 挑戦する
- 保護効果を評価するために特定の細菌群 (Clostridiales, Bacteroidales) を投与する.
- 成人マウスのクロストリディアルを枯渇させ,コロニー化抵抗性の必要性を評価する.
主要な成果:
- 新生児の微生物群は 成人の微生物群とは違って 病原体の植民を防ぐことができなかった.
- 新生児の微生物群にClostridialesが存在しないことは,植民抵抗性の欠如と相関している.
- 新生児のマウスを感染から保護し,腸内病理を減少させた.
- 成人マウスのクロストリディアルの枯渇は,彼らの植民地化抵抗性を廃止した.
- 新生児の腸内細菌は 保護性クロストリディアルの植民を促した.
結論:
- 腸内微生物群は 新生児のコロニー抵抗性において 免疫系の成熟度に関係なく 重要な役割を果たします
- クロストリディアルは,新生児と成人のマウスの両方でコロニー化抵抗性を確立するために不可欠です.
- クロストリディアルの標的投与は,新生児の感染を予防または治療するための治療戦略を提供することができる.
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