世代を超えた環境情報の伝達 エレガンス
Adam Klosin1,2, Eduard Casas3, Cristina Hidalgo-Carcedo1,2
1EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), European Molecular Biology Organization, 08003 Barcelona, Spain.
Science (New York, N.Y.)
|April 22, 2017
まとめ
環境の変化は,ネマトドの Caenorhabditis elegans の世代間の遺伝子発現を変化させる可能性があります. 温度の変化により遺伝的変化が起こり 遺伝的記憶が14世代以上続きます
科学分野:
- エピジェネティクス
- 発達生物学
- 遺伝学
背景:
- 環境要因は次の世代における遺伝子発現に影響を与える.
- ネマトド Caenorhabditis elegansは,世代を超えた遺伝を研究するためのモデル生物として機能しています.
研究 の 目的:
- カエノラブディティス・エレガンスの環境による表遺伝子変化の持続時間とメカニズムを調査する.
- 温度の影響による遺伝子発現の変化が 世代を超えて受け継がれるかどうかを判断する.
主な方法:
- モデル生物として使用した
- 温度の変化による遺伝子発現の変化
- 分析された遺伝子発現パターンとヒストンの改変 (H3K9me3).
- 少なくとも14世代に渡って 表現の変化の遺伝を追跡した.
主要な成果:
- ヘテロクロマティック遺伝子配列発現の温度誘発の変化は少なくとも14世代持続した.
- 遺伝はシスで発生し,卵細胞と精子の両方を通して発生した.
- ヒストンH3ライシン9トリメチル化 (H3K9me3) の変化は,ジゴティック転写前に観察されました.
- 表現プロファイリングは,内生的な抑制された繰り返しから遺伝された温度誘発表現を確認しました.
結論:
- Caenorhabditis elegansでは,環境の変化に関する長期間の表遺伝的記憶が可能である.
- 環境に起因する遺伝子発現の世代間継承は,表遺伝的メカニズムによって媒介される.
- ヒストンの改変は,ジゴティック遺伝子の活性化前に,この表遺伝子記憶を確立する役割を果たします.
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