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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

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AKT/PKBシグナリング:ネットワークをナビゲートする

Brendan D Manning1, Alex Toker2

  • 1Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Cell
|April 22, 2017
PubMed
まとめ
この要約は機械生成です。

AKTシグナル伝達ネットワークは,タンパク質キナーゼB (PKB) とも呼ばれ,細胞生物学と医学において極めて重要です. 癌や糖尿病のような病気を 治療するためには その複雑な調節と機能を 理解することが不可欠です

さらに関連する動画

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

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Identification of Kinase-substrate Pairs Using High Throughput Screening
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Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

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Last Updated: Feb 24, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

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Identification of Kinase-substrate Pairs Using High Throughput Screening
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Identification of Kinase-substrate Pairs Using High Throughput Screening

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科学分野:

  • 生物化学
  • 細胞生物学
  • 分子医学

背景:

  • セリン/スレオニンキナーゼAKT (タンパク質キナーゼB) は25年間広範に研究されている.
  • アップストリームレギュレータ,ダウンストリームエフェクター (GSK3,FoxO,mTORC1) と複雑なシグナリングネットワークの理解が進んでいる.
  • AKTネットワークは細胞のどこにでも存在し,臓器システム全体で生理学的役割を果たします.

研究 の 目的:

  • AKTシグナル伝達に関する広範な知識を見直す.
  • 様々な病気と治療開発における AKTの重要性を強調する.

主な方法:

  • 既存の文献と遺伝子研究 (マウスとヒト) のレビュー
  • AKTの規制入力,下流信号ノード,およびネットワーク回路の分析.
  • 様々な病理学的状態における AKT の役割の検討

主要な成果:

  • AKTの規制とその下流の信号伝達経路を理解する上で大きな進展がありました.
  • AKT機能不全は 癌,糖尿病,神経疾患など多くの疾患に 関わっている.
  • AKT選択性小分子阻害剤の開発は治療に有望である.

結論:

  • AKT信号ネットワークの包括的な理解は,生物医学研究にとって極めて重要です.
  • AKT経路の調節不全は 様々な病気の原因になります
  • AKTシグナル伝達に関する継続的な研究は,複数の科学分野と治療戦略に影響を及ぼします.