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Updated: Mar 3, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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GRK5を持つβ2アドレナリン受容体複合体の構造と機能分析

Konstantin E Komolov1, Yang Du2, Nguyen Minh Duc3

  • 1Department of Biochemistry and Molecular Biology and the Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Cell
|April 22, 2017
PubMed
まとめ

研究者らは,ベータ-2 アドレナージック受容体 (β2AR) と相互作用するGタンパク質結合受容体キナーゼ5 (GRK5) の分子機構を明らかにした. この研究は,GPCRシグナリングの調節に不可欠なダイナミックな複合体の形成と形状の変化を明らかにしています.

キーワード:
Gタンパク質結合受容体Gタンパク質結合受容体キナーゼクロスリンクマススペクトロメトリー分子動力学リン酸化β(2) - アドレナゲン受容体

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