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Updated: Mar 3, 2026

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

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プロテアゼ活性化受容体2のアロステリック調節に関する構造的洞察

Robert K Y Cheng1, Cédric Fiez-Vandal1, Oliver Schlenker1

  • 1Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.

Nature
|April 27, 2017
PubMed
まとめ

プロテアゼ活性化受容体2 (PAR2) 抗体に対する構造的な洞察は,小分子と抗体の新しい結合部位を明らかにした. これらの発見は,がんや炎症のような PAR2媒介性疾患の標的治療の開発に道を開きます.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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