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メラノコルチン1受容体シグナル伝達 マクロファージにおけるコレステロール輸送を調節する

Petteri Rinne1, Martina Rami2, Salla Nuutinen2

  • 1From Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (P.R., M.R., D.S., E.P.C.v.d.V., R.Q.-P., L.R., C.W., S.S.); Department of Pharmacology, Drug Development and Therapeutics, University of Turku and Turku University Hospital, Finland (P.R., S.N.); Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center, Tampere, Faculty of Medicine and Life Sciences, University of Tampere (L.-P.L., E.R., N.O., T.L.); Department of Surgery, Tampere University Hospital, Finland (N.O.); Department of Chemistry and Biochemistry, University of Arizona, Tucson (M.C., V.J.H.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (C.W., S.S.). pperin@utu.fi.

Circulation
|April 29, 2017
PubMed
まとめ

メラノコルチン1受容体 (MC1- R) の活性化は,コレステロールの吸収を減らし,マクロファージの排泄を促進することによって,動脈硬化から保護します. この二重作用は,泡細胞の形成を防止し,プラークの安定性を高めます.

キーワード:
動脈硬化症コレステロール炎症マクロファージ

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