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Updated: Mar 3, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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立体選択的に前薬を組み立てる多機能な触媒

Daniel A DiRocco1, Yining Ji2, Edward C Sherer2

  • 1Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA. daniel.dirocco@merck.com.

Science (New York, N.Y.)
|April 29, 2017
PubMed
まとめ

研究者らは,抗ウイルスおよび抗癌療法に不可欠なキラル・フォスフォラミダートの立体選択合成のための新しい触媒方法を開発しました. この画期的な発見は 薬の開発におけるステレオ化学を 精密に制御することを可能にしました

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