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Updated: Mar 3, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
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血小板由来成長因子受容体 β 核プロモーター核酸過敏要素のG四重複とiモチーフの重複の結果は,突然変異の予期せぬ効果を説明し,小分子による両方の構造の選択的標的化のための機会を提供し,遺伝子発現を抑制する

Robert V Brown1, Ting Wang2, Venkateshwar Reddy Chappeta1

  • 1College of Pharmacy, University of Arizona , 1703 East Mabel Street, Tucson, Arizona 85721, United States.

Journal of the American Chemical Society
|May 5, 2017
PubMed
まとめ

研究者らは,PDGFR-βプロモーターのG-四重複素とiモチーフを標的とした新しい化合物を特定し,PDGFR-βの活性を低下させることで,急性肺損傷のような疾患の治療の可能性を示した.

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