Thy-1+ dendritic epidermal 細胞のガンマデルタ抗原受容体遺伝子の多様性は限られている
D M Asarnow1, W A Kuziel, M Bonyhadi
1Department of Microbiology and Immunology, University of California, Berkeley 94720.
Cell
|December 2, 1988
まとめ
ネズミの皮膚のデンドリティック表皮細胞 (dECs) は,主に特定のT細胞受容体遺伝子を用いており,胎児の早期の胸腺移民から由来することを示唆しています. これは,他のT細胞タイプとは異なるユニークな免疫監視の役割を意味しています.
科学分野:
- 免疫学 免疫学とは
- T細胞生物学について
- 皮膚科 皮膚科について
背景:
- ガンマ・デルタ・T細胞は,周辺リンパ性組織のマイナーな集団であるが,表皮のような特定の上皮で主要な集団である.
- dendritic epidermal cells (dECs) の起源と特異的な機能は,T細胞研究の関心分野であり続けています.
研究 の 目的:
- T細胞受容体遺伝子の利用とネズミの dendritic epidermal cells (dECs) の潜在的な起源を調査する.
- 他のT細胞集団と比較して,dECsの独特の免疫監視役割を理解するために.
主な方法:
- ネズミのdECクローンで発現したVガンマおよびVデルタ遺伝子セグメントの分析.
- dEC受容体における再編成されたガンマおよびデルタ遺伝子の交差点の検査.
主要な成果:
- ミュアンのdECクローンは,VガンマおよびVデルタ遺伝子のセグメントを発現し,これは成人T細胞ではまれであるが,胎児のチモサイトでは一般的です.
- 分析された5つのdECクローンのT細胞受容体において,驚くべき均一性が観察されました.
- dEC T細胞受容体は,ガンマおよびデルタ遺伝子セグメントの明確な使用を示しています.
結論:
- データは,dECが胎児の早期の胸腺移住者であるというモデルを裏付けている.
- dECは,おそらく,表皮の特殊な免疫監視機能を有している.
- この機能は,アルファベータT細胞と他のガンマデルタT細胞とは異なる.
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