Psoriasis の冠動脈プラークの特徴は,前向きな観察研究で治療後に改善する高リスク特性を明らかにします
Joseph B Lerman1, Aditya A Joshi1, Abhishek Chaturvedi1
1From National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (J.B.L., A.A.J., A.C., T.M.A., A.K.D., J.A.R., T.S., J.H.C., A.R., H.L.T., M.P.P., M.Y.C., V.S., D.A.B., N.N.M.); Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, CA (J.J.W.); and DermAssociates, Silver Spring, MD (B.A.L.).
Circulation
|May 10, 2017
まとめ
牛皮病患者は,健康な人と比較して,非加熱冠動脈プラークの負担と高リスクのプラークの有病率が増加しています. 皮膚の炎症をコントロールすることで,冠動脈疾患のリスクを減らすことができます.
科学分野:
- 心血管研究
- 炎症性疾患
- 医療用画像検査
背景:
- 牛皮病は慢性炎症性疾患で,心筋梗塞のリスクが高くなります.
- 炎症性アテロゲネシスを研究するモデルとして使われています.
- 冠動脈病 (CAD) の非カルシフィケーションによる冠動脈病のリスクは,
研究 の 目的:
- 冠動脈のプラーク負荷を,牛皮病患者と高脂血症患者,そして健康なボランティアと比較する.
- これらのグループにおける非カルシフ化プラーク負担 (NCB) と高リスクプラーク (HRP) の流行を評価する.
- 牛皮病の重症度とCADの進行との関係を調査する.
主な方法:
- 冠動脈コンピュータ・トモグラフィー・アニオグラフィーは,プラークの定量化とHRPの識別に使用された.
- HRPは低衰弱,ポジティブリモデリング,斑点性カルシフィケーションによって定義された.
- 治療効果を評価するために1年後にスライド検査を繰り返した.
主要な成果:
- 低血脂症の患者よりNCBが高かったのは,若かったにもかかわらずでした.
- 牛皮の患者は,健康なボランティアの患者と比較して,プラークの総負荷,NCB,HRPの有病率が増加した.
- プラークの総負荷とNCBの減少と相関する疹の重度の改善
結論:
- 牛皮病患者は健康な人よりも非カルシフィー化冠動脈プラークと高リスクプラークの負担が大きい.
- 牛皮の患者は,NCBが上昇し,高齢の高脂血症患者と同様のHRPの罹患率を示しています.
- 牛皮病の皮膚炎を制御することで,冠動脈疾患のリスクが改善される可能性があります.
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