2つのオクソアニオンを密接に拘束するビスカリックス[4]ピロール酵素ミミク
Qing He1, Michael Kelliher1, Steffen Bähring1,2
1Department of Chemistry, The University of Texas at Austin , 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Journal of the American Chemical Society
|May 12, 2017
まとめ
新しいカプセル状の分子であるbis-calix[4]pyrrole 1は,二酸化水素,硫酸塩,およびパイロフォスファートを含む2つのアニオンを同時に結合することができる. この二重アニオン認識は,様々な光学および結晶学的方法を使用して確認されました.
科学分野:
- 超分子化学
- ホスト・ゲスト・ケミストリー
- アニオン認識
背景:
- カリックスピロールマクロサイクルは分子認識のための多用途のプラットフォームです.
- 複数のアニオンを同時に結合させる受容体の設計は大きな課題です.
研究 の 目的:
- 大きなカプセル状のビスカリックス[4]ピロール受容体を合成し,特徴づけること.
- 複数のアニオンを同時にホストする受容体の能力を調査する.
- 二重アニオン結合の構造的および電子的基礎を探求する.
主な方法:
- ビスカリックス[4]ピロール受容体の合成 1.
- スペクトル解析 (1H NMR,UV-vis)
- イソテルミック・タイトレーション・カロリメトリー (ITC)
- シングルクリスタルX線 difraktion
- 密度関数理論 (DFT) の計算
主要な成果:
- 受容体1は溶液中の二酸化水素アニオンを成功裏にホストした.
- 受容体はまた,2つの硫酸アニオンを結合し,固体と溶液で二重体を形成する.
- 受容体1は2つのトライアニオン酸塩アニオンを収容する能力を示した.
- 構造的および計算的研究により,結合モードと相互作用が解明されました.
結論:
- Bis-calix[4]pyrrole 1は,同時ダブルアニオン結合に優れた能力を発揮している.
- 受容体の大きな穴と構造的特徴により,様々なポリアニオンが認識できます.
- この研究は,複雑なアニオン認識の課題に対する 洗練された宿主分子の設計を進めている.
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
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