組織修復と再構築におけるマクロファージの機能には,アポプトティック細胞を持つIL-4またはIL-13が必要です
Lidia Bosurgi1, Y Grace Cao1, Mar Cabeza-Cabrerizo1
1Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
まとめ
インタールイウキン-4 (IL-4) とIL-13は,アポプトシス細胞と結合して,マクロファージの組織修復を活性化します. ヘルミントの感染や大腸炎では,アポプトシス細胞を感知することがこのプロセスに不可欠です.
科学分野:
- 免疫学
- 細胞生物学
- 組織 の 修復 機構
背景:
- インタールイウキン-4 (IL- 4) とIL- 13は,ヘルミントの感染に対する宿主反応における重要なサイトカインである.
- 組織修復は複雑なプロセスで 様々な細胞や分子成分が関与しています
研究 の 目的:
- マクロファージにおけるIL-4/IL-13誘発の組織修復プログラムにおけるアポプトシス細胞の役割を調査する.
- 感染や炎症時にマクロファージの増殖と遺伝子誘導のためのアポプトシス細胞センサーの必要性を決定する.
主な方法:
- マウスモデルにおけるアポプトシス細胞センサーの遺伝子切除を活用した.
- マクロファージの増殖,遺伝子発現 (抗炎症,組織修復,PRR,粘着,化学作用) と肺および腸の組織における宿主反応を分析した.
- マクロファージの機能に対するIL-4/IL-13とアポプトティック細胞の相乗効果を調査した.
主要な成果:
- IL-4またはIL-13は単独では不十分であり,アポプトシス細胞との組み合わせにより,マクロファージの組織修復プログラムが誘発された.
- アポプトシス細胞センサーの遺伝的消去は,組織内マクロファージの増殖と抗炎症および組織修復遺伝子の誘導を阻害した.
- アポプトティック細胞認識は,IL-4/IL-13によるパターン認識受容体,細胞結合,または化学作用遺伝子の誘導に不可欠ではありませんでした.
結論:
- アポプトシス細胞の検出は,マクロファージ媒介の組織修復を開始する際に,IL-4/IL-13と共に重要な共同因子である.
- この認識メカニズムは空間的にサイトカインの活動を調節し,早発または子宮外反応を予防します.
- 発見は,炎症を制御し,ヘルミント感染症や炎症性疾患の治癒を促進するための新しい経路を強調しています.
関連する概念動画
Phagocytosis of Apoptotic Cells
5.4K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
5.4K
Inflammatory Response
17.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.6K
T Cell Types and Functions
2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Immune Surveillance by NK Cells and Phagocytes
9.1K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.1K
Inflammation
62.9K
Overview
62.9K
Cells of the Innate Immune Response
9.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.8K


