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ヒトGLP-1受容体トランスメブランドメイン構造は,アロステル型調節剤の複合体である

Gaojie Song1, Dehua Yang2, Yuxia Wang1

  • 1iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.

Nature
|May 18, 2017
PubMed
まとめ

グルカゴン型ペプチド-1受容体 (GLP-1R) の構造的な洞察は,ネガティブなアロステル調節剤の共通の結合部位を明らかにする. この発見は,受容体の機能を理解し,新しい2型糖尿病治療法を開発するのに役立ちます.

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