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Updated: Mar 2, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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チラクトンベースのマクロリド抗生物質の化学酵素的総合成と構造的多様化,後期ポリケチド組立,調整,C-H機能化

Andrew N Lowell1, Matthew D DeMars1, Samuel T Slocum1

  • 1Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|May 20, 2017
PubMed
まとめ

この研究では,ポリケチド合成酵素 (PKS) を用いてマクロリド抗生物質を合成し,ジュベニミシン,M-4365,ロサミシン等を初めて完全合成した. 化学酵素学的アプローチにより これらの複雑な自然製品の 拡張可能な製造が可能になりました

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