背骨二面角の協同制御によるペプトイド正方形ヘリックス

Benjamin C Gorske¹, Emily M Mumford¹, Charles G Gerrity¹

¹Department of Chemistry, Bowdoin College , 6600 College Station, Brunswick, Maine 04011-8466, United States.

Journal of the American Chemical Society

|May 25, 2017

まとめ

研究者は新しいペプトイド折り畳み二次構造である η-ヘリクスを開発し,先進的な材料と医薬品に予測可能な制御と多様な機能を提供しました.

科学分野:

マクロ分子化学とナノ科学
合成ポリマー化学

背景:

新しい二次構造の開発は先進的な材料,分子機械,医薬品に不可欠です.
合成の折りたたみ器は設計と機能の多様性において優れているが,予測制御の原則は欠けている.

研究の目的:

折り畳み式二次構造の合理的かつモジュラーな制御を確立する.
多様な機能を持つ新しい折り畳み式二次構造を導入する.

主な方法:

ペプトイド折りたたみ合成における2つの設計原理の相乗効果的応用.
溶液相構造の決定は,シミュレートアニリングとNOEによる距離制限を使用します.
採用した二次構造を確認するためにNMRスペクトロスコーピー.

主要な成果:

新しい二次構造である η-ヘリクスは,ペプトイドの折りたたみで成功裏に設計され合成されました.
η-ヘリクスは,ペプチドのβ-ターンに似た繰り返しターンを示している.
構造分析は,様々な条件で安定している η-ヘリックス構造の主要な採用を確認しました.

結論:

開発された設計原理は,ペプトイド折りたたみ二次構造に対する合理的な制御を可能にします.
η-ヘリクスは安定した,合成的にアクセス可能な構造で,様々な用途の可能性がある.
この研究は,革新的な材料科学と生物医学アプリケーションのための折り畳み器の設計を進めている.

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